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Article

A comprehensive analysis of common genetic variation around six candidate loci for intrahepatic cholestasis of pregnancy.

The American journal of gastroenterology - 1 Jan 2014

Dixon Peter H, Wadsworth Christopher A, Chambers Jennifer, Donnelly Jennifer, Cooley Sharon, Buckley Rebecca, Mannino Ramona, Jarvis Sheba, Syngelaki Argyro, Geenes Victoria, Paul Priyadarshini, Sothinathan Meera, Kubitz Ralf, Lammert Frank, Tribe Rachel M, Ch'ng Chin Lye, Marschall Hanns-Ulrich, Glantz Anna, Khan Shahid A, Nicolaides Kypros, Whittaker John, Geary Michael, Williamson Catherine

Abstract excerpt

OBJECTIVES: Intrahepatic cholestasis of pregnancy (ICP) has a complex etiology with a significant genetic component. Heterozygous mutations of canalicular transporters occur in a subset of ICP cases and a population susceptibility allele (p.444A) has been identified in ABCB11. We sought to expand our knowledge of the detailed genetic contribution to ICP by investigation of common variation around candidate loci...

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Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 11

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Source

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Identifiers

PMID: 24366234
DOI: 10.1038/ajg.2013.406
PMCID: PMC3887577

Genes

ABCB11
ABCB4
ABCC2
FGF19

Provenance

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