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Genetic study of intrahepatic cholestasis of pregnancy in Chinese women unveils East Asian etiology linked to historic HBV epidemic.

Journal of hepatology - 1 May 2025

Liu Yanhong, Wei Yuandan, Chen Xiaohang, Huang Shujia, Gu Yuqin, Yang Zijing, Guo Xinxin, Zheng Hao, Feng Hanxiao, Huang Mingxi, Chen Shangliang, Xiao Tiantian, Hu Liang, Zhang Quanfu, Zhang Yang, Chen Guo-Bo, Qiu Xiu, Wei Fengxiang, Zhen Jianxin, Liu Siyang

Abstract excerpt

BACKGROUND & AIMS: Intrahepatic cholestasis of pregnancy (ICP) is the most common and high-risk liver disorder during pregnancy, with varying prevalence across populations. Our understanding of the mechanisms underlying ICP and population-level differences remains limited. This study delves into the genetic etiology of ICP in East Asians, drawing comparisons with Europeans to comprehend ICP etiology in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39547589
DOI: 10.1016/j.jhep.2024.11.008

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