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Article

Shared and Distinct Genetic Factors Underlying Bile Acid Regulation and Intrahepatic Cholestasis of Pregnancy.

Genetic epidemiology - 1 Jun 2026

Zhang Xinyi, Li Junwei, Zhu Huanhuan, Li Linxuan, Wang Yu, Yang Meng, Wang Lin, Lan Xianmei, Wang Yingying, Lin Ying, Zeng Jingyu, Liu Panhong, Zhou Aifen, Xiao Han, Jin Xin

Abstract excerpt

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by elevated total bile acid (TBA) levels, leading to adverse maternal and fetal outcomes. While genetic factors contribute to ICP and bile acid metabolism, the underlying mechanisms remain incompletely understood, particularly in East Asian populations. We conducted a genome-wide association study (GWAS) in 13,357...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42076915
DOI: 10.1002/gepi.70040

Genes

SLC39A9
CYP7A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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