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Germline APOE ε2 homozygosity and reduced risk of breast cancer: a population-based cohort study.

Breast cancer research : BCR - 22 May 2026

Woo Hwamin, Han Suhyun, Heo Jihye, Cho Juhee, Kim Do-Geun, Kim Chi-Hun, Kang Danbee

Abstract excerpt

We evaluated whether Apolipoprotein E (APOE) ε2 homozygosity, a germline variant associated with lower LDL cholesterol, is linked to reduced risk of breast cancer. We analyzed data from 234,857 cancer-free and dementia-free women in the UK Biobank. APOE genotypes were classified as ε2 homozygotes, ε2 heterozygotes, and non-ε2 carriers. Incident breast cancer was assessed via national registry linkage. Cox...

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Identifiers

PMID: 42174632
DOI: 10.1186/s13058-026-02308-6
PMCID: PMC13371704

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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