Article

The linker histone H1.4 condenses chromatin in maturing postmitotic neurons

2026-07-29

Abstract excerpt

<h4>ABSTRACT</h4> H1 histones are abundant nuclear proteins that bind to linker DNA at the entry and exit points of nucleosomes. Although individual H1 family members play partially redundant roles in chromatin organization, the discovery of disease-associated mutations in H1 genes has raised interest in their cell-type specific functions. Heterozygous, de novo frameshift mutations in H1-4 cause the neurodevelop...

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Literature Corpus work: aa01c6f4-13f4-54a6-9190-8828c6dbd163
DOI: 10.64898/2026.07.28.741367

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