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Article

Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons.

Science advances - 22 May 2026

Sichlinger Laura, Hausherr Maximilian, Guerrisi Sara, Dutan-Polit Lucia, Chennell George, Nagy Roland, Matuleviciute Rugile, Nasser Fatema, Farkas Szidonia, Bamford Rosemary A, Leung Szi Kay, Duarte Rodrigo R R, Powell Timothy R, Mill Jonathan, Marcus Katrin, Vernon Anthony C, Srivastava Deepak P

Abstract excerpt

ZNF804A was among the first genes robustly associated with schizophrenia based on findings from large-scale genomic studies. Previous research has implicated ZNF804A in the regulation of gene expression and synaptic function, but the role of this gene in neurodevelopment and in schizophrenia pathogenesis remains unclear. To study its function during neurodevelopment, we generated isogenic human induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42160410
DOI: 10.1126/sciadv.aea0755
PMCID: PMC13189102

Genes

ZNF804A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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