Article
Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment.
Molecular psychiatry - 1 Apr 2018
Zhou Y, Dong F, Lanz T A, Reinhart V, Li M, Liu L, Zou J, Xi H S, Mao Y
Abstract excerpt
Recent genome-wide association studies identified over 100 genetic loci that significantly associate with schizophrenia (SZ). A top candidate gene, ZNF804A, was robustly replicated in different populations. However, its neural functions are largely unknown. Here we show in mouse that ZFP804A, the homolog of ZNF804A, is required for normal progenitor proliferation and neuronal migration. Using a yeast two-hybrid...
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