Article

Schizophrenia-linked protein tSNARE1 regulates endolysosomal trafficking in cortical neurons

2021-02-12

Abstract excerpt

TSNARE1 , which encodes the protein tSNARE1, is a high-confidence gene candidate for schizophrenia risk, but nothing is known about its cellular or physiological function. We identified the major gene products of TSNARE1 and their cytoplasmic localization and function in endolysosomal trafficking in murine cortical neurons. We validated four primary isoforms of TSNARE1 expressed in human brain, all of which enco...

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Literature Corpus work: b6de09e1-1e39-5d38-8d75-0c01d7a26dfb
DOI: 10.1101/2021.02.09.430442

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