Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two structurally mobile regions control the conformation and function of metamorphic meiotic HORMAD proteins.

Nature communications - 19 May 2026

Barroso Consuelo, Prince Josh P, Rattu Punam, Sacerdoti Mariana, Koundé Daimona, Ferrandiz Nuria, Lopez-Jimenez Pablo, Khalid Syma, Martinez-Perez Enrique

Abstract excerpt

Metamorphic HORMA domain proteins (HORMADs) nucleate protein complex formation by refolding their mobile safety belt region to bind short closure motifs on interactors. Meiotic HORMADs (mHORMADs) bind proteinaceous axial elements to orchestrate complex chromosomal events that underpin fertility, including pairing and recombination between homologous chromosomes. However, the mechanisms supporting the diverse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Proteins

Share to Meiosis

Share to Molecular Dynamics Simulation

Share to Protein Binding

Share to Protein Conformation

Share to Protein Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 42156730
DOI: 10.1038/s41467-026-72656-6
PMCID: PMC13381836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two structurally mobile regions control the conformation and function of metamorphic meiotic HORMAD proteins.PMID 42156730Read ↗

The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins.Semantic proximity Read ↗

A nuclear TRiC/CCT chaperonin assembles meiotic HORMAD proteins into chromosome axes competent for crossing overSemantic proximity Read ↗

A conserved filamentous assembly underlies the structure of the meiotic chromosome axis.Semantic proximity Read ↗

Meiotic chromosome homology search involves modifications of the nuclear envelope protein Matefin/SUN-1.Semantic proximity Read ↗

Cooperation between Caenorhabditis elegans COMPASS and condensin in germline chromatin organizationSemantic proximity Read ↗

Aberrant activation of chromosome asynapsis checkpoint triggers oocyte eliminationSemantic proximity Read ↗

Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.Semantic proximity Read ↗

Cooperation between C <i>aenorhabditis elegans</i> COMPASS and condensin in germline chromatin organizationSemantic proximity Read ↗

PCH-2 collaborates with CMT-1 to proofread meiotic homolog interactions.Semantic proximity Read ↗

Germline maintenance through the multifaceted activities of GLH/Vasa in <i>Caenorhabditis elegans</i> P granulesSemantic proximity Read ↗

HTP-1-dependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. elegans meiosis.Semantic proximity Read ↗

Condensins regulate meiotic DNA break distribution, thus crossover frequency, by controlling chromosome structure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.