Article

A nuclear TRiC/CCT chaperonin assembles meiotic HORMAD proteins into chromosome axes competent for crossing over

2025-03-03

Abstract excerpt

The meiotic chromosome axis organizes chromatin and sets the stage for homolog pairing and recombination. M eiotic HORMA d omain proteins (mHORMADs) are conserved axis components that conformationally transform during target binding. In C. elegans, four functionally distinct mHORMADs directly interact, but how binding between them is restricted to axis assembly is unknown. Using a mutation in the mHORMADs that...

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Literature Corpus work: 8ae54d4b-51ca-527b-b62a-ae6c438bba42
DOI: 10.1101/2025.03.03.641182

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