Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins.

Developmental cell - 24 Nov 2014

Kim Yumi, Rosenberg Scott C, Kugel Christine L, Kostow Nora, Rog Ofer, Davydov Vitaliy, Su Tiffany Y, Dernburg Abby F, Corbett Kevin D

Abstract excerpt

Proteins of the HORMA domain family play central, but poorly understood, roles in chromosome organization and dynamics during meiosis. In Caenorhabditis elegans, four such proteins (HIM-3, HTP-1, HTP-2, and HTP-3) have distinct but overlapping functions. Through combined biochemical, structural, and in vivo analysis, we find that these proteins form hierarchical complexes through binding of their HORMA domains to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Proteins

Share to Chromosome Pairing

Share to Chromosome Segregation

Share to Chromosomes

Share to Meiosis

Share to Synaptonemal Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 25446517
DOI: 10.1016/j.devcel.2014.09.013
PMCID: PMC4254552

Genes

HORMAD1
HORMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins.PMID 25446517Read ↗

A conserved filamentous assembly underlies the structure of the meiotic chromosome axis.Semantic proximity Read ↗

Two structurally mobile regions control the conformation and function of metamorphic meiotic HORMAD proteins.Semantic proximity Read ↗

A nuclear TRiC/CCT chaperonin assembles meiotic HORMAD proteins into chromosome axes competent for crossing overSemantic proximity Read ↗

Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.Semantic proximity Read ↗

HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis.Semantic proximity Read ↗

Aberrant activation of chromosome asynapsis checkpoint triggers oocyte eliminationSemantic proximity Read ↗

A component of C. elegans meiotic chromosome axes at the interface of homolog alignment, synapsis, nuclear reorganization, and recombination.Semantic proximity Read ↗

Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2.Semantic proximity Read ↗

The telomere bouquet is a hub where meiotic double-strand breaks, synapsis, and stable homolog juxtaposition are coordinated in the zebrafish, Danio rerioSemantic proximity Read ↗

The axial element protein HTP-3 promotes cohesin loading and meiotic axis assembly in C. elegans to implement the meiotic program of chromosome segregation.Semantic proximity Read ↗

Conserved HORMA domain-containing protein Hop1 stabilizes interaction between proteins of meiotic DNA break hotspots and chromosome axis.Semantic proximity Read ↗

The telomere bouquet is a hub where meiotic double-strand breaks, synapsis, and stable homolog juxtaposition are coordinated in the zebrafish, <i>Danio rerio</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.