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Article

Condensins regulate meiotic DNA break distribution, thus crossover frequency, by controlling chromosome structure.

Cell - 2 Oct 2009

Mets David G, Meyer Barbara J

Abstract excerpt

Meiotic crossover (CO) recombination facilitates evolution and accurate chromosome segregation. CO distribution is tightly regulated: homolog pairs receive at least one CO, CO spacing is nonrandom, and COs occur preferentially in short genomic intervals called hotspots. We show that CO number and distribution are controlled on a chromosome-wide basis at the level of DNA double-strand break (DSB) formation by a...

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Share to Adenosine Triphosphatases
Share to Caenorhabditis elegans Proteins
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crossing Over, Genetic

Share to DNA Breaks, Double-Stranded

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Source

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Identifiers

PMID: 19781752
DOI: 10.1016/j.cell.2009.07.035
PMCID: PMC2785808

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