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Aberrant activation of chromosome asynapsis checkpoint triggers oocyte elimination

6 Mar 2025

Abstract excerpt

Chromosome synapsis is an evolutionarily conserved process essential for meiotic recombination. HORMAD1 and HORMAD2, which monitor chromosome asynapsis by localizing to unsynapsed chromosome axes, are removed from synapsed chromosome axes by TRIP13, though the biological significance of this process remains unclear. We show that when HORMAD1 and HORMAD2 are retained on synapsed chromosome axes, they recruit...

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PMID: 40050306
DOI: 10.1038/s41467-025-57702-z

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