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Article

MTHFR risk alleles associate with Th17 immunity and spinal damage in axial spondyloarthritis.

Clinical immunology (Orlando, Fla.) - 1 Aug 2026

Sun Ting, Wu Yuxian, Wang Jingtong, Yin Jian, Gao Jie, Tang Gusheng, Liu Yang, Liu Yaoyang

Abstract excerpt

BACKGROUND: MTHFR polymorphisms regulate homocysteine metabolism, yet their role in clinical heterogeneity, immune dysregulation, and treatment outcomes in axial spondyloarthritis (axSpA) remains undefined. METHODS: This cross-sectional study included 180 axSpA patients and a retrospective TNF inhibitor (TNFi) cohort (n = 50). CD4+ T-cell subsets were profiled by flow cytometry. Patients were stratified by...

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Identifiers

PMID: 42155831
DOI: 10.1016/j.clim.2026.110725

Genes

MTHFR
CD4
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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