The effects of the MTHFR 677C>T (rs1801133) genetic variant on susceptibility and disability worsening in multiple sclerosis patients are mediated by homocysteine.

doi:10.1016/j.msard.2024.105883

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The effects of the MTHFR 677C>T (rs1801133) genetic variant on susceptibility and disability worsening in multiple sclerosis patients are mediated by homocysteine.

Multiple sclerosis and related disorders - 1 Nov 2024

Ribeiro Claudia Mara, Oliveira Sayonara Rangel, Flauzino Tamires, Alfieri Daniela Frizon, Simão Andrea Name Colado, Lozovoy Marcell Alysson Batisti, Maes Michael, Reiche Edna Maria Vissoci

Abstract excerpt

BACKGROUND: Interactions between genetic and environmental variables contribute to the autoimmune inflammatory process in multiple sclerosis (MS). Elevated homocysteine levels, and vitamin D, vitamin B12, and folate deficiencies are some of the environmental factors associated with the pathogenesis of MS. Considering that the relationship between MTHFR 677C>T (rs1801133) genetic variant, homocysteine, and folate...

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PMID: 39270536
DOI: 10.1016/j.msard.2024.105883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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