Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability.

Pharmacogenetics and genomics - 1 Apr 2012

Becker Mara L, van Haandel Leon, Gaedigk Roger, Thomas Bradley, Hoeltzel Mark F, Lasky Andrew, Dai Hongying, Stobaugh John, Leeder James S

Abstract excerpt

OBJECTIVE: Methotrexate (MTX) has several enzymatic targets in the folate pathway. To better understand the variability in response to MTX, we characterized the interindividual variability of intracellular folate pools in children with juvenile arthritis (JA) and determined clinical and genetic c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Juvenile
Share to Ferredoxin-NADP Reductase
Share to Folic Acid Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metabolic Networks and Pathways

Share to Methotrexate

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Oxidation-Reduction

Share to Tetrahydrofolates

Source

Identifiers

PMID: 22344247
DOI: 10.1097/FPC.0b013e3283500202

Genes

MTHFR
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22344247-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability.PMID 22344247Read ↗

The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.Semantic proximity Read ↗

Effect of Genetic Polymorphisms in the Folate Pathway on Methotrexate Therapy in Rheumatic DiseasesSemantic proximity Read ↗

Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis.Semantic proximity Read ↗

Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexateSemantic proximity Read ↗

Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis.Semantic proximity Read ↗

Methotrexate pharmacogenetics in rheumatoid arthritis: a status report.Semantic proximity Read ↗

MTX pathway gene variants, erythrocyte methotrexate polyglutamates, and treatment outcomes in rheumatoid arthritis.Semantic proximity Read ↗

Factors Underlying Failure of Methotrexate Treatment in Rheumatoid Arthritis: Implications in Personalized CareSemantic proximity Read ↗

Contribution of common polymorphisms in reduced folate carrier and ??-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritisSemantic proximity Read ↗

Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis.Semantic proximity Read ↗

Role of methotrexate polyglutamation and reduced folate carrier 1 (RFC1) gene polymorphisms in clinical assessment indexes.Semantic proximity Read ↗

Methotrexate Triglutamate as a Determinant of Clinical Response in Mexican Patients With Rheumatoid Arthritis: Pharmacokinetics and Dose Recommendation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.