Article
Genetic variants in the TNF pathway impact TNFi response in a mixed population with rheumatoid arthritis.
Gene - 30 Nov 2024
Augusto Silva Dos Santos Rodrigues Pedro, Lima de Oliveira Almirane, Mattos Brandão Katarina, de Sá Garcia Landeiro Lilian, Cardoso Calmon Laryssa, Victor Andrade Cruz João, Dos Anjos Silva Mailane, Flávia Silva Rocha Ana, Silva Carvalho de Souza Deyse, Tupiná Alcântara de Moreira Aramis, de Oliveira Santos Junison, Miranda Barbosa Dos Santos Thamara, Pimentel Pinheiro Gabriela, Augusto Souza da Cruz Filho Álvaro, Alexandrina Viana de Figueiredo Camila, de Moura Santos Pablo, Dos Santos Costa Ryan
Abstract excerpt
Rheumatoid arthritis (RA) is a multifactorial autoimmune inflammatory disease that mainly affects the joints, on reducing functional capacity and impacting quality of life. Cytokines such as tumor necrosis factor (TNF) and interleukin 6 (IL-6) are crucial in the pathogenesis and treatment of this disease. Some patients using TNF inhibitors (TNFi) do not respond or lose their response to these medications....
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