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Article

MTHFR c.665C>T and c.1298A>C Polymorphisms in Tailoring Personalized Anti-TNF-α Therapy for Rheumatoid Arthritis.

International journal of molecular sciences - 18 Feb 2023

Ravaei Amin, Pulsatelli Lia, Assirelli Elisa, Ciaffi Jacopo, Meliconi Riccardo, Salvarani Carlo, Govoni Marcello, Rubini Michele

Abstract excerpt

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease with a prevalence of 1%. Currently, RA treatment aims to achieve low disease activity or remission. Failure to achieve this goal causes disease progression with a poor prognosis. When treatment with first-line drugs fails, treatment with tumor necrosis factor-α (TNF-α) inhibitors may be prescribed to which many patients do not respond adequately,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 36835522
DOI: 10.3390/ijms24044110
PMCID: PMC9962934

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