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MTHFR, TYMS and SLCO1B1 polymorphisms and adverse liver effects of methotrexate in rheumatoid arthritis.

Pharmacogenomics - 1 Apr 2020

Sundbaum Johanna Karlsson, Baecklund Eva, Eriksson Niclas, Hallberg Pär, Kohnke Hugo, Wadelius Mia

Abstract excerpt

Aims: To investigate whether variants of MTHFR, TYMS and SLCO1B1 are associated with ALT elevation in rheumatoid arthritis patients starting methotrexate (MTX). Patients & methods: Clinical and laboratory data were collected from the start of MTX treatment. Genotyping of MTHFR, TYMS and SLCO1B1 was performed. Univariate and multiple logistic regression were used for statistical analysis. Results: 34 out of 369...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32024416
DOI: 10.2217/pgs-2019-0186

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