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Article

No evidence for a causal link between plasma lipids and multiple sclerosis susceptibility and severity: A Mendelian randomisation study.

Journal of the neurological sciences - 15 Aug 2026

Nagrodzki Jakub, Proitsi Petroula, Tan Manuela, Dobson Ruth, Jacobs Benjamin M

Abstract excerpt

BACKGROUND: Observational studies suggest that alterations in circulating lipid levels may be associated with multiple sclerosis (MS) susceptibility and severity. OBJECTIVES: Our study employs two-sample Mendelian randomisation (MR) to investigate whether these relationships are causal. METHODS: Genetic instruments for 249 metabolites, predominantly lipids and lipoproteins, were obtained from a combined dataset...

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PMID: 42142449
DOI: 10.1016/j.jns.2026.125986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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