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Article

Multiple sclerosis as a genetic risk factor for Alzheimer's disease: Insights from Mendelian randomisation.

Neurodegenerative disease management - 1 Oct 2025

Rajavoor Muniswamy Jai Kumar, Reshi Amrutha, Roy Chowdhury Dibyendu, Kumar-M Praveen

Abstract excerpt

BACKGROUND: Inflammation is implicated in neurodegeneration, but the causal link between multiple sclerosis and Alzheimer's disease remains unclear. OBJECTIVE: To investigate the genetic relationship between MS and AD using Mendelian Randomization and assess downstream molecular effects. METHODS: Two-sample MR was conducted using GWAS summary statistics, with IVW and MR Egger methods. Sensitivity analyses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40685710
DOI: 10.1080/17582024.2025.2530350
PMCID: PMC12456208

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