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Article

Phenome-wide Mendelian randomisation analysis identifies causal factors for age-related macular degeneration.

eLife - 27 Jan 2023

Julian Thomas H, Cooper-Knock Johnathan, MacGregor Stuart, Guo Hui, Aslam Tariq, Sanderson Eleanor, Black Graeme C M, Sergouniotis Panagiotis I

Abstract excerpt

Background: Age-related macular degeneration (AMD) is a leading cause of blindness in the industrialised world and is projected to affect >280 million people worldwide by 2040. Aiming to identify causal factors and potential therapeutic targets for this common condition, we designed and undertook a phenome-wide Mendelian randomisation (MR) study. Methods: We evaluated the effect of 4591 exposure traits on early...

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Identifiers

PMID: 36705323
DOI: 10.7554/eLife.82546
PMCID: PMC9883012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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