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Article

A metabolome-wide Mendelian randomization study prioritizes potential causal circulating metabolites for multiple sclerosis.

Journal of neuroimmunology - 15 Jun 2023

Ge Angela, Sun Yitang, Kiker Thaddaeus, Zhou Yanjiao, Ye Kaixiong

Abstract excerpt

To prioritize circulating metabolites that likely play causal roles in the pathogenesis of multiple sclerosis (MS). Two-sample Mendelian randomization analysis was performed to estimate the causal effects of 571 circulating metabolites on the risk of MS. Genetic instruments for circulating metabolites were obtained from three previous genome-wide association studies (GWAS) of the blood metabolome (N = 7824;...

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Genome-Wide Association Study
Lysine
Mendelian Randomization Analysis
Metabolome
Multiple Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 37207441
DOI: 10.1016/j.jneuroim.2023.578105
PMCID: PMC10237183

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