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Article

DeepCLIP: predicting the effect of mutations on protein-RNA binding with deep learning.

Nucleic acids research - 27 Jul 2020

Grønning Alexander Gulliver Bjørnholt, Doktor Thomas Koed, Larsen Simon Jonas, Petersen Ulrika Simone Spangsberg, Holm Lise Lolle, Bruun Gitte Hoffmann, Hansen Michael Birkerod, Hartung Anne-Mette, Baumbach Jan, Andresen Brage Storstein

Abstract excerpt

Nucleotide variants can cause functional changes by altering protein-RNA binding in various ways that are not easy to predict. This can affect processes such as splicing, nuclear shuttling, and stability of the transcript. Therefore, correct modeling of protein-RNA binding is critical when predicting the effects of sequence variations. Many RNA-binding proteins recognize a diverse set of motifs and binding is...

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Identifiers

PMID: 32558887
DOI: 10.1093/nar/gkaa530
PMCID: PMC7367176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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