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Article

Individual S-acylated cysteines differentially contribute to H-Ras endomembrane trafficking and acylation/deacylation cycles.

Molecular biology of the cell - 1 Apr 2017

Pedro Maria P, Vilcaes Aldo A, Gomez Guillermo A, Daniotti Jose L

Abstract excerpt

S-acylation/deacylation cycles and vesicular transport are critical for an adequate subcellular distribution of S-acylated Ras proteins. H-Ras is dually acylated on cysteines 181 and 184, but it is unknown how these residues individually contribute to H-Ras trafficking. In this study, we characterized the acylation and deacylation rates and membrane trafficking of monoacylated H-Ras mutants to analyze their...

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Identifiers

PMID: 28179458
DOI: 10.1091/mbc.E16-08-0603
PMCID: PMC5385944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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