Article
Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function.
Circulation research - 17 Jul 2009
Singaraja Roshni R, Kang Martin H, Vaid Kuljeet, Sanders Shaun S, Vilas Gonzalo L, Arstikaitis Pamela, Coutinho Jonathan, Drisdel Renaldo C, El-Husseini Alaa El Din, Green William N, Berthiaume Luc, Hayden Michael R
Abstract excerpt
ATP-binding cassette transporter (ABC)A1 lipidates apolipoprotein A-I both directly at the plasma membrane and also uses lipids from the late endosomal or lysosomal compartment in the internal lipidation of apolipoprotein A-I. However, how ABCA1 targeting to these specific membranes is regulated remains unknown. Palmitoylation is a dynamically regulated lipid modification that targets many proteins to specific...
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