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Article

Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway.

The Journal of cell biology - 18 Jul 2005

Goodwin J Shawn, Drake Kimberly R, Rogers Carl, Wright Latasha, Lippincott-Schwartz Jennifer, Philips Mark R, Kenworthy Anne K

Abstract excerpt

Palmitoylation is postulated to regulate Ras signaling by modulating its intracellular trafficking and membrane microenvironment. The mechanisms by which palmitoylation contributes to these events are poorly understood. Here, we show that dynamic turnover of palmitate regulates the intracellular trafficking of HRas and NRas to and from the Golgi complex by shifting the protein between vesicular and nonvesicular...

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Identifiers

PMID: 16027222
DOI: 10.1083/jcb.200502063
PMCID: PMC2171405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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