S-palmitoylation coordinates the trafficking of ATG9A to mediate autophagy initiation

Abstract excerpt

Macroautophagy (hereafter autophagy), a major intracellular catabolic process, is evolutionarily conserved from yeast to mammals and is associated with a broad range of human diseases. Autophagy is morphologically characterized by the formation of double-membrane autophagosomes. ATG9A, a multi-spanning transmembrane protein and lipid scramblase, is a core component of the autophagy machinery that complements...

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