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Article

Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling.

Molecular and cellular biology - 1 Aug 2005

Roy Sandrine, Plowman Sarah, Rotblat Barak, Prior Ian A, Muncke Cornelia, Grainger Sarah, Parton Robert G, Henis Yoav I, Kloog Yoel, Hancock John F

Abstract excerpt

H-ras is anchored to the plasma membrane by two palmitoylated cysteine residues, Cys181 and Cys184, operating in concert with a C-terminal S-farnesyl cysteine carboxymethylester. Here we demonstrate that the two palmitates serve distinct biological roles. Monopalmitoylation of Cys181 is required and sufficient for efficient trafficking of H-ras to the plasma membrane, whereas monopalmitoylation of Cys184 does not...

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Identifiers

PMID: 16024806
DOI: 10.1128/MCB.25.15.6722-6733.2005
PMCID: PMC1190337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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