Immunophenotypic, Genetic, and Clinical Features Associated With RUNX1 Mutation in Acute Leukemias and Chronic Myeloid Neoplasms.

Abstract excerpt

INTRODUCTION: RUNX1 is a commonly mutated transcriptional regulator of hematopoiesis in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Mutated RUNX1 (mRUNX1) may associate with cross-lineage immunophenotypic aberrancy, presenting potential complications for blast lineage assignment at diagnosis. METHODS: Clinical and laboratory data were reviewed for patients with RUNX1 mutations (N = 125) at...

Topics

• Humans
• Core Binding Factor Alpha 2 Subunit
• Immunophenotyping
• Female
• Leukemia, Myeloid, Acute
• Mutation