Characterisation and prognostic impact Of ZRSR2 mutations in myeloid neoplasms

Abstract excerpt

The ZRSR2 gene, located on the X chromosome (Xp22.1), is a member of the RNA splicing machinery family of genes which also includes SF3B1 , SRSF2 , and U2AF1 [ 1 , 2 , 3 ]. Spliceosome gene mutations are found in 35% of myelodysplastic syndrome (MDS) patients and were described as being mutually exclusive with each other [ 3 , 4 ]. ZRSR2m is seen in 4% of MDS, and across different myeloid neoplasms (MN) including...

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