RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes.

doi:10.3324/haematol.2012.064667

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes.

Haematologica - 1 Dec 2012

Greif Philipp A, Konstandin Nikola P, Metzeler Klaus H, Herold Tobias, Pasalic Zlatana, Ksienzyk Bianka, Dufour Annika, Schneider Friederike, Schneider Stephanie, Kakadia Purvi M, Braess Jan, Sauerland Maria Cristina, Berdel Wolfgang E, Büchner Thomas, Woermann Bernhard J, Hiddemann Wolfgang, Spiekermann Karsten, Bohlander Stefan K

Abstract excerpt

BACKGROUND: The RUNX1 (AML1) gene is a frequent mutational target in myelodysplastic syndromes and acute myeloid leukemia. Previous studies suggested that RUNX1 mutations may have pathological and prognostic implications. DESIGN AND METHODS: We screened 93 patients with cytogenetically normal acute myeloid leukemia for RUNX1 mutations by capillary sequencing of genomic DNA. Mutation status was then correlated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Myeloid, Acute

Share to Nucleophosmin

Share to Oligonucleotide Array Sequence Analysis

Share to Remission Induction

Share to Survival Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 22689681
DOI: 10.3324/haematol.2012.064667
PMCID: PMC3590097

Genes

RUNX1
BLNK
DNTT
HOPX
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes.PMID 22689681Read ↗

RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group.Semantic proximity Read ↗

RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features.Semantic proximity Read ↗

The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies.Semantic proximity Read ↗

Somatic Exonic Deletions in RUNX1 Constitutes a Novel Recurrent Genomic Abnormality in Acute Myeloid Leukemia.Semantic proximity Read ↗

RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making.Semantic proximity Read ↗

Frequency and Clinicopathologic Features of RUNX1 Mutations in Patients With Acute Myeloid Leukemia Not Otherwise Specified.Semantic proximity Read ↗

Comparison of mutational profiles and clinical outcomes in patients with acute myeloid leukemia with mutated RUNX1 versus acute myeloid leukemia with myelodysplasia-related changes with mutated RUNX1.Semantic proximity Read ↗

Acute Leukemias of Ambiguous Lineage With RUNX1 Mutations Show Similar Prognosis Compared to Acute Myeloid Leukemia With RUNX1 Mutations: A Study From the Bone Marrow Pathology Group.Semantic proximity Read ↗

AML1/RUNX1 Mutations in 470 Adult Patients with De Novo Acute Myeloid Leukemia: Prognostic Implication and Interaction with Other Gene Alterations.Semantic proximity Read ↗

RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures.Semantic proximity Read ↗

Distinct association of RUNX family expression with genetic alterations and clinical outcome in acute myeloid leukemia.Semantic proximity Read ↗

Investigations of the prognostic value of RUNX1 mutation in acute myeloid leukemia patients: Data from a real-world study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.