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Article

Causal Links of Type 2 Diabetes and Its Complications With Cortical Modification: A Mendelian Randomization and Mediation Analysis.

Brain and behavior - 1 May 2026

Huang Hong, Huang Hanyu, Gong Yanlin, Zhou Tengteng, Liang Yundan, Wang Yichao

Abstract excerpt

BACKGROUND: Type 2 diabetes (T2D) and its complications are linked to cognitive decline over time, accompanied by cortical abnormalities. The causality between T2D and cortical modifications, however, remains elusive. METHODS: Applying two-sample Mendelian randomization (MR), we probed causal relationships between T2D and its complications and cortical modifications. Genetic associations were elucidated via...

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42135912
DOI: 10.1002/brb3.71389
PMCID: PMC13176085

Genes

CD4
IL20RA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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