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Integrating immune-cell transcriptomic data with Mendelian randomisation reveals novel causal genes for type 2 diabetes and its complications.

Diabetologia - 1 Aug 2026

Ding Yilan, Liu Haoyu, Jiang Lei, Yang Qian, Wang Shuangyuan, Lin Hong, Li Mian, Zhao Zhiyun, Wang Tiange, Xu Min, Xu Yu, Ning Guang, Wang Weiqing, Bi Yufang, Zheng Jie, Lu Jieli

Abstract excerpt

AIMS/HYPOTHESIS: The aim of this study was to facilitate the fine classification of diabetic complications and the prioritisation of drug targets via immune-cell-related gene expression data, distinguishing cell-type-related pleiotropy. METHODS: We analysed the combined clinical, genetic and immune-related features of diabetic complications, generating distinct clusters. Using 18,611 immune expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42118257
DOI: 10.1007/s00125-026-06747-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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