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Article

Diagnostic accuracy of 2-hydroxyglutarate magnetic resonance spectroscopy in newly diagnosed brain mass and suspected recurrent gliomas.

Neuro-oncology - 2 Aug 2018

Zhou Min, Zhou Yue, Liao Huijun, Rowland Benjamin C, Kong Xiangquan, Arvold Nils D, Reardon David A, Wen Patrick Y, Lin Alexander P, Huang Raymond Y

Abstract excerpt

Background: Isocitrate dehydrogenase (IDH) mutations result in abnormal accumulation of 2-hydroxyglutarate (2HG) in gliomas that can be detected by MRS. We examined the diagnostic accuracy of 2HG single-voxel spectroscopy (SVS) and chemical shift imaging (CSI) in both newly diagnosed and posttreatment settings. Methods: Long echo time (97 ms) SVS and CSI were acquired in 85 subjects, including a discovery cohort...

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Identifiers

PMID: 29438510
DOI: 10.1093/neuonc/noy022
PMCID: PMC6071662

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