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Article

Preoperative Determination of Isocitrate Dehydrogenase Mutation in Gliomas Using Spectral Editing MRS: A Prospective Study.

Journal of magnetic resonance imaging : JMRI - 1 Feb 2021

Nguyen Thanh B, Melkus Gerd, Taccone Michael, Moldovan Ioana D, Ghinda Diana, Gotfrit Ryan, Torres Carlos H, Zakhari Nader, Chakraborty Santanu, Woulfe John, Jansen Gerard, McInnes Matthew Df, Thornhill Rebecca E, Cameron Ian, AlKherayf Fahad

Abstract excerpt

BACKGROUND: The edited magnetic resonance spectroscopy (MRS) technique has not yet been formally evaluated for the in vivo detection of 2-hydroxyglutarate (2-HG) in patients with gliomas of various grades. PURPOSE: To evaluate the diagnostic accuracy of edited MRS in the preoperative identification of the isocitrate dehydrogenase (IDH) mutation status in patients with gliomas. STUDY TYPE: Prospective. POPULATION:...

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PMID: 32940938
DOI: 10.1002/jmri.27366

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