Impaired glucose tolerance in women with BRCA1 versus BRCA2 pathogenic or likely pathogenic variants: Results from a prospective cohort study.

doi:10.1007/s10689-026-00570-3

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Impaired glucose tolerance in women with BRCA1 versus BRCA2 pathogenic or likely pathogenic variants: Results from a prospective cohort study.

Familial cancer - 14 May 2026

Grandi Giovanni, Piombino Claudia, Sighinolfi Giovanna, Barbieri Elena, Venturelli Marta, Melotti Chiara, Lippi Bruni Rebecca, Grisendi Valentina, Cuoghi Costantini Riccardo, Grippa Mina, Zattarin Emma, Tenedini Elena, Razzaboni Elisabetta, Brigante Giulia, D'Amico Roberto, Nanni Benedetta, Menozzi Renata, Cortesi Laura, Dominici Massimo, La Marca Antonio, Toss Angela

Abstract excerpt

BACKGROUND: Estrogens exert a beneficial effect on metabolism. Women carrying BRCA likely pathogenic/pathogenic variants (LP/PV) are at increased risk of premature menopause and may therefore be at higher risk of developing metabolic disorders later in life. In this single-center prospective cohort study, we investigated whether the specific BRCA mutation (BRCA1 vs. BRCA2) has a differential impact on metabolism...

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Identifiers

PMID: 42132994
DOI: 10.1007/s10689-026-00570-3
PMCID: PMC13176168

Genes

BRCA1
BRCA2

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