Article
Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium.
Breast cancer research : BCR - 20 Jun 2023
Kast Karin, John Esther M, Hopper John L, Andrieu Nadine, Noguès Catherine, Mouret-Fourme Emmanuelle, Lasset Christine, Fricker Jean-Pierre, Berthet Pascaline, Mari Véronique, Salle Lucie, Schmidt Marjanka K, Ausems Margreet G E M, Garcia Encarnacion B Gomez, van de Beek Irma, Wevers Marijke R, Evans D Gareth, Tischkowitz Marc, Lalloo Fiona, Cook Jackie, Izatt Louise, Tripathi Vishakha, Snape Katie, Musgrave Hannah, Sharif Saba, Murray Jennie, Colonna Sarah V, Andrulis Irene L, Daly Mary B, Southey Melissa C, de la Hoya Miguel, Osorio Ana, Foretova Lenka, Berkova Dita, Gerdes Anne-Marie, Olah Edith, Jakubowska Anna, Singer Christian F, Tan Yen, Augustinsson Annelie, Rantala Johanna, Simard Jacques, Schmutzler Rita K, Milne Roger L, Phillips Kelly-Anne, Terry Mary Beth, Goldgar David, van Leeuwen Flora E, Mooij Thea M, Antoniou Antonis C, Easton Douglas F, Rookus Matti A, Engel Christoph
Abstract excerpt
INTRODUCTION: Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes. PATIENTS AND METHODS: An international pooled cohort of 8091 BRCA1/2 variant carriers was used for retrospective and prospective analyses separately for premenopausal and...
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