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Article

The Potential Role of Vitamin D in BRCA1 Pathogenic Variant Carriers: A Narrative Review.

International journal of molecular sciences - 19 Jun 2026

Robaczyńska Joanna, Kiljańczyk Milena, Maj Maciej, Kiljańczyk Adam, Byrski Tomasz, Cybulski Cezary, Janiuk Izabela, Gronwald Jacek, Lubiński Jan

Abstract excerpt

Vitamin D is a fat-soluble secosteroid essential for skeletal development and calcium homeostasis, but it also exerts pleiotropic effects on numerous biological processes via its active metabolites. Vitamin D metabolites act as steroid hormones that regulate cell-cycle progression, proliferation, differentiation, apoptosis, immune responses, and multiple intracellular signaling pathways. Moreover, they modulate...

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42353259
DOI: 10.3390/ijms27125545
PMCID: PMC13300645

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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