Article
An association between a common variant (G972R) in the IRS-1 gene and sex hormone levels in post-menopausal breast cancer survivors.
Breast cancer research and treatment - 1 Oct 2006
Fan Jing, McKean-Cowdin Roberta, Bernstein Leslie, Stanczyk Frank Z, Li Arthur Xuejun, Ballard-Barbash Rachel, McTiernan Anne, Baumgartner Richard, Gilliland Frank
Abstract excerpt
Insulin receptor substrate-1 (IRS-1) is a key downstream signaling molecule common to both the insulin and IGF signaling pathways that can interact with the estrogen pathway to regulate breast cell growth. We investigated whether a putative functional variant for IRS-1 (G972R) influences circulating levels of sex hormones, sex hormone binding globulin (SHBG), C-peptide, and insulin-like growth factor 1 (IGF-1)...
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