Article
HNRNPU mutations redirect cell cycle control to E2F in MYC-driven lymphomas.
Blood advances - 14 Jul 2026
Qureshi Qurat Ul Ain, Coyle Krysta M, Brown Callum, Thomas Nicole, Collinge Brett, Dreval Kostiantyn, Steidl Christian, Scott David W, Audas Timothy E, Morin Ryan D
Abstract excerpt
ABSTRACT: Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is a ubiquitously expressed, pleiotropic DNA and RNA binding protein involved in RNA metabolism. Heterozygous HNRNPU nonsense mutations have been observed in a variety of B-cell lymphomas, but the functional consequence of these mutations remains largely unknown. Through a large meta-analysis of genome- and exome-wide sequencing data, we find that these...
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