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Article

Genomic hallmarks and therapeutic targets of ribosome biogenesis in cancer.

Briefings in bioinformatics - 22 Jan 2024

Zang Yue, Ran Xia, Yuan Jie, Wu Hao, Wang Youya, Li He, Teng Huajing, Sun Zhongsheng

Abstract excerpt

Hyperactive ribosome biogenesis (RiboSis) fuels unrestricted cell proliferation, whereas genomic hallmarks and therapeutic targets of RiboSis in cancers remain elusive, and efficient approaches to quantify RiboSis activity are still limited. Here, we have established an in silico approach to conveniently score RiboSis activity based on individual transcriptome data. By employing this novel approach and RNA-seq...

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Identifiers

PMID: 38343327
DOI: 10.1093/bib/bbae023
PMCID: PMC10859687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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