Article
Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression.
Nature genetics - 1 Dec 2023
Leeman-Neill Rebecca J, Song Dong, Bizarro Jonathan, Wacheul Ludivine, Rothschild Gerson, Singh Sameer, Yang Yang, Sarode Aditya Y, Gollapalli Kishore, Wu Lijing, Zhang Wanwei, Chen Yiyun, Lauring Max C, Whisenant D Eric, Bhavsar Shweta, Lim Junghyun, Swerdlow Steven H, Bhagat Govind, Zhao Qian, Berchowitz Luke E, Lafontaine Denis L J, Wang Jiguang, Basu Uttiya
Abstract excerpt
Whole-genome sequencing of longitudinal tumor pairs representing transformation of follicular lymphoma to high-grade B cell lymphoma with MYC and BCL2 rearrangements (double-hit lymphoma) identified coding and noncoding genomic alterations acquired during lymphoma progression. Many of these transformation-associated alterations recurrently and focally occur at topologically associating domain resident regulatory...
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