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Article

HNRNPC and m6A RNA methylation control oncogenic transcription and metabolism in T-cell leukemia

28 May 2025

Abstract excerpt

ABSTRACT: RNA homeostasis is dysregulated in cancer and affects disease progression and therapy resistance. N6-methyladenosine (m6A), the most abundant epitranscriptomic modification in eukaryotic messenger RNA, plays a pivotal role in RNA biology, affecting transcript stability, translation, and splicing. Our study uncovers the extensive m6A changes in patients with T-cell acute lymphoblastic leukemia (T-ALL),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40435411
DOI: 10.1182/blood.2024026848

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