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The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability

29 Apr 2024

Abstract excerpt

BACKGROUND: TP53, the most frequently mutated gene in human cancers, orchestrates a complex transcriptional program crucial for cancer prevention. While certain TP53-dependent genes have been extensively studied, others, like the recently identified RNF144B, remained poorly understood. This E3 ubiquitin ligase has shown potent tumor suppressor activity in murine Eμ Myc-driven lymphoma, emphasizing its...

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PMID: 38685100
DOI: 10.1186/s13046-024-03045-4

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