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Article

Sex-Specific Patterns of Taste Dysfunction, Their Relationships with α-Synuclein Profiling, and Supervised Learning-Based Diagnosis in Parkinson's Disease (PD).

International journal of molecular sciences - 30 Apr 2026

Melis Melania, Angius Fabrizio, Naciri Lala Chaimae, Sollai Giorgia, Deligia Silvia, Fenu Giuseppe, Mellino Paolo, Pinna Beatrice, Crnjar Roberto, Carta Anna R, Cossu Giovanni, Tomassini Barbarossa Iole

Abstract excerpt

Taste impairment is a little-known non-motor Parkinson's disease (PD) feature with potential diagnostic value. However, its biological basis and sex-specific patterns remain unclear. We combined psychophysical taste testing, salivary α synuclein (αsyn) profiling, genotyping of four SNCA polymorphisms, and Supervised Learning (SL) within a unified, sex-aware analytical framework to analyze sensory, molecular, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42123627
DOI: 10.3390/ijms27094048
PMCID: PMC13164297

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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