Article
Association of Olfactory Performance With Motor Decline and Age at Onset in People With Parkinson Disease and the LRRK2 G2019S Variant.
Neurology - 23 Aug 2022
Saunders-Pullman Rachel, Ortega Roberto Angel, Wang Cuiling, Raymond Deborah, Elango Sonya, Leaver Katherine, Urval Nikita, Katsnelson Viktoriya, Gerber Rachel, Swan Matthew, Shanker Vicki, Alcalay Roy N, Mirelman Anat, Brumm Michael C, Mejia-Santana Helen, Coffey Christopher S, Marek Kenneth, Ozelius Laurie J, Giladi Nir, Marder Karen S, Bressman Susan B
Abstract excerpt
BACKGROUND AND OBJECTIVES: There is clinical and phenotypic heterogeneity in LRRK2 G2019S Parkinson disease (PD), including loss of smell. Olfactory scores have defined subgroups of LRRK2 PD at baseline. We now extend this work longitudinally to better determine features associated with olfactory classes and to gain further insight into this heterogeneity. METHODS: Evaluation of 162 patients with LRRK2 PD and 198...
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