Article
A multi-dimensional study on taste deficits, α-synuclein genetic profiling, and supervised learning for diagnosis and disease severity stratification in Parkinson's disease (PD).
Neurobiology of disease - 1 Dec 2025
Naciri Lala Chaimae, Melis Melania, Sollai Giorgia, Deligia Silvia, Fenu Giuseppe, Mellino Paolo, Pinna Beatrice, Crnjar Roberto, Cossu Giovanni, Barbarossa Iole Tomassini
Abstract excerpt
Parkinson's disease (PD) is a complex neurological condition. Alfa-synuclein, and specifically the salivary oligomeric form, have been described as biomarkers of PD, and their genetic mutations have been associated with PD susceptibility. Taste impairments are less studied and have produced inconsistent results, and their diagnostic and prognostic significance remains underexplored. We evaluated taste perceptions...
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