Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Associations Between OPN-CD44 Axis Genetic Variability, Plasma Osteopontin, and Treatment Outcomes in Head and Neck Squamous Cell Carcinoma.

International journal of molecular sciences - 22 Apr 2026

Gdowicz-Kłosok Agnieszka, Deja Regina, Rutkowski Tomasz, Bugowska Magdalena, Mrochem-Kwarciak Jolanta, Składowski Krzysztof, Butkiewicz Dorota

Abstract excerpt

Inter-individual variability in outcomes following radiotherapy-based treatment remains a major challenge in head and neck squamous cell carcinoma (HNSCC). Osteopontin (OPN) and its receptor CD44 are key mediators of tumor progression, hypoxia-related treatment resistance, and metastatic dissemination. In this exploratory, hypothesis-generating study, we investigated selected functional polymorphisms in OPN...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Hyaluronan Receptors

Share to Osteopontin

Share to Prognosis

Share to Squamous Cell Carcinoma of Head and Neck

Share to Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 42123308
DOI: 10.3390/ijms27093724
PMCID: PMC13164495

Genes

CD44
SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Associations Between OPN-CD44 Axis Genetic Variability, Plasma Osteopontin, and Treatment Outcomes in Head and Neck Squamous Cell Carcinoma.PMID 42123308Read ↗

Common Variants in Osteopontin and CD44 Genes as Predictors of Treatment Outcome in Radiotherapy and Chemoradiotherapy for Non-Small Cell Lung CancerSemantic proximity Read ↗

Osteopontin promoter polymorphisms at locus -443 significantly affect the metastasis and prognosis of human hepatocellular carcinoma.Semantic proximity Read ↗

Genetic Signatures: CD44 Single-Nucleotide Polymorphisms Affect Cell Surface Expression and Elevate Risk in Head and Neck Squamous Cell Carcinoma.Semantic proximity Read ↗

Osteopontin is a prognostic biomarker in non-small cell lung cancer.Semantic proximity Read ↗

Germline polymorphisms in genes involved in the CD44 signaling pathway are associated with clinical outcome in localized gastric adenocarcinoma.Semantic proximity Read ↗

Role of osteopontin in the pathophysiology of cancerSemantic proximity Read ↗

Correlation between OPN gene polymorphisms and the risk of nasopharyngeal carcinoma.Semantic proximity Read ↗

An osteopontin promoter polymorphism is associated with aggressiveness in breast cancer.Semantic proximity Read ↗

The implication of osteopontin (OPN) expression and genetic polymorphisms of OPN promoter in oral carcinogenesis.Semantic proximity Read ↗

Genetic polymorphisms in the osteopontin promoter increases the risk of distance metastasis and death in Chinese patients with gastric cancer.Semantic proximity Read ↗

Human osteopontin: Potential clinical applications in cancer (Review)Semantic proximity Read ↗

Osteopontin genetic variants are associated with overall survival in advanced non-small-cell lung cancer patients and bone metastasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.