Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline polymorphisms in genes involved in the CD44 signaling pathway are associated with clinical outcome in localized gastric adenocarcinoma.

International journal of cancer - 1 Sept 2011

Winder Thomas, Ning Yan, Yang Dongyun, Zhang Wu, Power Derek G, Bohanes Pierre, Gerger Armin, Wilson Peter M, Lurje Georg, Tang Laura H, Shah Manish, Lenz Heinz-Josef

Abstract excerpt

The cluster of differentiation 44 (CD44) signaling pathway is crucial in cancer-cell growth, invasion, proliferation and metastasis. CD44 is a transmembrane receptor for hyaluronan and osteopontin, and has recently attracted attention as a gastric cancer stem cell marker. Previous studies showed that polymorphisms in the CD44 gene can influence both human cancer survival and determine cellular response to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Hyaluronan Receptors

Share to Neoplasm Recurrence, Local

Share to Polymorphism, Restriction Fragment Length

Share to Prognosis

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 21105049
DOI: 10.1002/ijc.25787
PMCID: PMC3139396

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline polymorphisms in genes involved in the CD44 signaling pathway are associated with clinical outcome in localized gastric adenocarcinoma.PMID 21105049Read ↗

Association of Two CD44 Polymorphisms with Clinical Outcomes of Gastric Cancer PatientsSemantic proximity Read ↗

Quantitative assessment of CD44 genetic variants and cancer susceptibility in Asians: a meta-analysis.Semantic proximity Read ↗

Clinicopathological and prognostic value of CD44 gene polymorphism (rs187115) in Swedish patients with colorectal cancer.Semantic proximity Read ↗

Common polymorphisms in CD44 gene and susceptibility to cancer: A systematic review and meta-analysis of 45 studies.Semantic proximity Read ↗

CD44 Genotypes Are Associated with Susceptibility and Tumor Characteristics in Colorectal Cancer Patients.Semantic proximity Read ↗

Impact of CD44 genetic variants on clinicopathological characteristics of uterine cervical cancer patients.Semantic proximity Read ↗

An individual coding polymorphism and the haplotype of the SPARC gene predict gastric cancer recurrence.Semantic proximity Read ↗

Genetic Signatures: CD44 Single-Nucleotide Polymorphisms Affect Cell Surface Expression and Elevate Risk in Head and Neck Squamous Cell Carcinoma.Semantic proximity Read ↗

CD44 single nucleotide polymorphism and isoform switching may predict gastric cancer recurrence.Semantic proximity Read ↗

Common Variants in Osteopontin and CD44 Genes as Predictors of Treatment Outcome in Radiotherapy and Chemoradiotherapy for Non-Small Cell Lung CancerSemantic proximity Read ↗

The Role of CD44 in the Pathogenesis, Diagnosis, and Therapy of Gastric CancerSemantic proximity Read ↗

Polymorphisms at the microRNA binding-site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.